Best of EASL Monothematic Conference: Cholangiocytes in health and disease: from basic science to novel treatments
EASL LiverTree™, Dr. J.M. Banales, Prof. Dr. P.L. Jansen, Prof. N.F. Larusso, Dr. M. Marzioni, 186698
Concluding Remarks
EASL LiverTree™, Peter L Jansen, 183780
Principles of value based medicine as applied to cholangiopathies
EASL LiverTree™, Mario Strazzabosco, 183778
Cell transplantation
EASL LiverTree™, Domenico Alvaro, 183776
Cholestatic drug induced liver injury
EASL LiverTree™, Raúl J Andrade, 183775
The future of therapy for cholangiopathies
EASL LiverTree™, Michael Trauner, 183774
Assessment of hepatic secretion function with 11C-cholylsarcosine PET/CT
EASL LiverTree™, Michael Soerensen, 183773
Biomarkers for cholangiopathies and cholangiocarcinoma
EASL LiverTree™, Daniel Gotthardt, 183772
The anti-inflammatory receptor TREM-2 protects the liver from cholestatic injury in mice
EASL LiverTree™, Aitor Esparza-Baquer, 177617
CD86+/CD206+ tumor-associated macrophages predict prognosis of patients with intrahepatic cholangiocarcinoma
EASL LiverTree™, Dalong Sun, 177618
Fluoroscopically guided biopsies do not seem to improve cancer detection rates in patients with biliary strictures undergoing brush cytology during ERCP
EASL LiverTree™, Daniela Reis, 177619
Hepatoprotective effect of S-Adenosyl L-Methionine (SAMe) in oxidative stress: in vitro study on hepatocytes and cholangiocytes
EASL LiverTree™, Ewa Kilanczyk, 177620
Anti-apoptotic role of c-FLIP in human cholangiocarcinoma: activation of Fas/FasL pathway
EASL LiverTree™, Gianluca Carnevale, 177621
Epigentic profiling of premalignant and malignant stages of cholangiocarcinoma
EASL LiverTree™, Ursula J. Lemberger, 177623
The endoscopist and malignant and non-malignant biliary obstructions
EASL LiverTree™, Stephen Pereira, 183769
Cholangiocarcinoma: Epidemiological trends and clinical management
EASL LiverTree™, Shahid A Khan, 183768
Genetics of familial cholangiopathies
EASL LiverTree™, Frank Lammert, 183767
Cholangiopathies in children
EASL LiverTree™, Richard Thompson, 183766
Tumour stroma in cholangiocarcinoma: A novel therapeutic target
EASL LiverTree™, Joachim C. Mertens, 183763
Chemoresistance and chemosensitization in cholangiocarcinoma
EASL LiverTree™, Jose J.G. Marin, 183762
Stem cell origin of cholangiocarcinoma
EASL LiverTree™, Tania Roskams, 183761
EASL LiverTree™, Ronald Oude Elferink, 184937
Target molecules in cholangiocarcinoma cells
EASL LiverTree™, Gregory Gores, 183760
Identification of tumour suppressive and oncogenic microRNAs in gallbladder carcinoma
EASL LiverTree™, Benjamin Goeppert, 177610
Biliary micorhamartomas (Von-Meyenburg complexes) are frequently associated with intrahepatic and hilar cholangiocarcinomas in liver
EASL LiverTree™, Joanna Gibson, 177611
The positive effect of exosomes on epithelial-mesenchymal transition through hedgehog signalling in cholangiocarcinoma cells
EASL LiverTree™, Özlem Kücükoglu, 177612
ATP Binding Cassette B4 (ABCB4) related disease – from genetics to phenotypic variability: a case series
EASL LiverTree™, Pedro Marques da Costa, 177613
Liver transplantation in patients with hilar cholangiocarcinoma- single center experience
EASL LiverTree™, Ana Ostojic, 177614
Liver progenitor cells significantly contribute to hepatocyte pool in chronic liver injury and cirrhosis: a kinetic study in mice
EASL LiverTree™, Rita Manco, 177615
Preliminary results from application of image processing tools and quantitative analysis of MRCP datasets of various aetiologies
EASL LiverTree™, Andy McKay, 177616
Bile acid homeostasis and immunity of the liver
EASL LiverTree™, Christoph Schramm, 183756
Mucosal immunity of the biliary tree in normality and disease
EASL LiverTree™, David Adams, 183754
The bile acid receptor TGR5 regulates paracellular permeability and protects the liver through an impact on the tight junction protein JAM-A
EASL LiverTree™, Grégory Merlen, 183751
Chronic treatment with clinic dose of metformin completely reverses the epithelial to mesenchymal transition (EMT) in human intrahepatic cholangiocarcinomas (iCCAs) by activated AMPK / Foxo3a pathway
EASL LiverTree™, Sabina Di Matteo, 183750
Inhibition of Src tyrosine kinase restores CFTR function in cystic fibrosis cholangiocytes derived from human induced pluripotent stem cells (iPSC) and improves the response to CFTR potentiators and correctors used in therapy
EASL LiverTree™, Romina Fiorotto, 183749
The role of ageing in the pathophysiology of the biliary epithelium: identification of a molecular profile
EASL LiverTree™, Luca Maroni, 183748
Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma
EASL LiverTree™, Ander Arbelaiz, 183747
3D-reconstruction of the murine biliary tree during cholestasis using two different techniques: corrosion casts and Microfil®-MV. Methods' descriptions and first results
EASL LiverTree™, Beate Richter, 177603
Colesevelam attenuates cholestatic liver and bile duct injury in Mdr2-/- mice by modulating composition, signaling and excretion of fecal bile acids
EASL LiverTree™, Michael Trauner, 177604
S-Adenosyl L-Methionine-induced protein S-glutathionylation may modulate immune responses in patients with primary biliary cholangitis
EASL LiverTree™, Ewa Kilanczyk, 177605
Precision-cut bile duct slices as a model to study regeneration of bile ducts of human donor livers after ischemic preservation injury
EASL LiverTree™, Iris de Jong, 177606
Autoimmune hepatitis: Evaluation of specificity of various histological features and development of a modified scoring system
EASL LiverTree™, Joanna Gibson, 177607
Splanchnic release contributes to the elevated pool of FGF19 in the circulation of patients with obstructive cholestasis
EASL LiverTree™, Kiran Koelfat, 177608
Hypothermic oxygenated machine perfusion reduces biliary reperfusion injury after transplantation of donation after circulatory death livers
EASL LiverTree™, Rianne Van Rijn, 177609
Yap is essential for cholangiocyte homeostasis and its removal leads to loss of ductal integrity and compensatory biliary cell expansion
EASL LiverTree™, Brian Joseph Pepe-Mooney, 177597
Tridimensional cultures of human biliary tree and hepatic stem/progenitor cells in simulated microgravity perpetuated the stem features and reduced the metabolic oxidation
EASL LiverTree™, Daniele Costantini, 177598
PGC-1β promotes development of hepatocellular carcinoma limiting ROS detrimental accumulation
EASL LiverTree™, Elena Piccinin, 177599
Characterization of the mitochondrial phenotype in primary biliary cholangitis patients' cholangiocytes
EASL LiverTree™, Filip Wysokinski, 177600
Differential effects of FXR or TGR5 activation in cholangiocarcinoma progression
EASL LiverTree™, Ibone Labiano, 177601
Relationship of IMP3 and HER3 expression with TH17 cells in cholangiocarcinomas
EASL LiverTree™, Yulian Ananiev, 177602
Bile acid-induced nephropathy
EASL LiverTree™, Peter Fickert, 183745
Heart and bile acids
EASL LiverTree™, Catherine Williamson, 183744
The molecular mechanism of cholestatic itch
EASL LiverTree™, Ronald Oude Elferink, 183743
The autophagy marker predicts tumor recurrence in intrahepatic cholangiocarcinoma patients after surgical resection
EASL LiverTree™, Chih Wen Lin, 177569
High-throughput sequencing analysis of tissue-resident gut and liver B cells reveals antigen-driven clonal expansion in primary sclerosing cholangitis-inflammatory bowel disease
EASL LiverTree™, Brian K. Chung, 177589
The crucial role of KITENIN in cholangiocarcinogenesis
EASL LiverTree™, Khac Cuong Bui, 177590
Identification and in silico characterization of six novel GANAB mutations in polycystic liver disease
EASL LiverTree™, Liyanne Van de Laarschot, 177591
MiRNA-506 promotes primary biliary cholangitis (PBC)-like features in cholangiocytes and immune activation
EASL LiverTree™, Oihane Erice, 177592
Role of the ciliopathy protein MKS1 in the homeostasis of bile duct epithelia
EASL LiverTree™, Pascale Dupuis-Williams, 177593
Sox9 is a crucial transcription factor in development of intrahepatic cholangiocarcinoma
EASL LiverTree™, Xiaodong Yuan, 177595
Whole transcriptome analysis of ductular reaction from patients with alcoholic hepatitis. Similarities to ductular reaction in DDC mouse model
EASL LiverTree™, Beatriz Aguilar, 177582
TWEAK/Fn14 signalling drives chemokine secretion in cholangiocarcinoma
EASL LiverTree™, Benjamin James Dwyer, 177583
Type I interferons are sensitive inflammatory biomarkers in primary sclerosing cholangitis
EASL LiverTree™, Christina Mehrfeld, 177584
SOX17 selectively sensitizes cholangiocarcinoma cells to anticancer drugs by interfering with promoter activation of the export pumps ABCC3 and ABCG2
EASL LiverTree™, Elisa Lozano, 177585
Alagille syndrome results in loss of polarity of cholangiocytes, rather than cholangiocyte loss per se
EASL LiverTree™, Emma R Andersson, 177586
Protein kinase CK2 as potential therapeutic target in cholangiocarcinoma
EASL LiverTree™, Giovanni Di Maira, 177587
Defects in protein processing may underlie the development of hepatic cysts in patients with polycystic liver disease
EASL LiverTree™, Liyanne Van de Laarschot, 177588
Bile acids, FGF15/19 and liver regeneration: from mechanisms to clinical applications
EASL LiverTree™, Matias A Avila, 183741
TGR5 in physiology and disease
EASL LiverTree™, Verena Keitel, 183740
Gut and liver interactions
EASL LiverTree™, Antonio Moschetta, 183739
Role of endoscopic ultrasound with fine needle aspiration for non mass-forming cholangiocarcinomas
EASL LiverTree™, Andrea Telese, 177575
Early identification of candidates for second-line therapies in PBC using a 'UDCA-response' model
EASL LiverTree™, Marco Carbone, 177576
microRNA-21 is overexpressed in primary biliary cholangitis and contributes to liver injury and necroptosis in cholestatic bile duct-ligated mice
EASL LiverTree™, Marta Afonso, 177577
Serial changes in liver stiffness measured by transient elastography and acoustic radiation force impulse imaging in patients with cholestasis
EASL LiverTree™, Mira Atef Shafik, 177578
Simultaneous deletion of tight junction proteins ZO-1 and ZO-2 in hepatocytes results in the desintegration of the intrahepatic biliary system
EASL LiverTree™, Noémi Van Hul, 177579
Sensitive detection of cholangiocarcinoma using DNA methylation biomarkers in bile
EASL LiverTree™, Trine Folseraas, 177580
A familial syndrome of primary sclerosing cholangitis with a heterozygous germline mutation in SEMA4D
EASL LiverTree™, Xiaojun Jiang, 177581
Combined targeting of cholangiocytes and activated stromal fibroblasts with a Bcl-xL inhibitor ameliorates liver fibrosis in Mdr2-/- mice
EASL LiverTree™, Anja Moncsek, 177568
Autotaxin activity predicts transplant-free survival in primary sclerosing cholangitis
EASL LiverTree™, Johannes R. Hov, 177570
Natural Killer T cells are activated in mice with cholestasis
EASL LiverTree™, Laura Valestrand, 177571
Auto-antibodies of the IgG4 and IgG1 subclass against Annexin A11 in IgG4-related disease of the biliary tract and pancreas
EASL LiverTree™, Lowiek Hubers, 177572
Circulating cancer-associated large extracellular vesicles in cholangiocarcinoma
EASL LiverTree™, Sabine Katharina Urban, 177573
Cellular senescence exacerbates injury and impairs regeneration in biliary disease
EASL LiverTree™, Sofia Ferreira-González, 177574
Pathogenesis and 3D structure of biliary fibrosis
EASL LiverTree™, Massimo Pinzani, 183735
Genetics and mechanisms of biliary cystogenesis: Impact in the clinical practice
EASL LiverTree™, Joost PH Drenth, 183734
Animal models of biliary injury and altered bile acid metabolism
EASL LiverTree™, Luca Fabris, 183731
CHOP deficiency protects against bile duct ligation-induced cholestatic liver injury by rescuing ER stress-induced loss of intestinal epithelial stemness
EASL LiverTree™, Huiping Zhou, 177561
NAD+/NADH redox status represents an abridged metabolic index that regulates intrinsic apoptosis in human cholangiocytes
EASL LiverTree™, Jung-Chin Chang, 177562
The CDE-induced liver injury causes impaired canalicular bile flow and expansion of small biliary branches that connect to intralobular canaliculi to drain bile
EASL LiverTree™, Laure-Alix Clerbaux, 177563
Identification of AGXT as a putative target in the Mdr2-/- murine model of liver cancer
EASL LiverTree™, Letizia Satriano, 177564
Risk reduction with obeticholic acid treatment in patients with primary biliary cholangitis not achieving the POISE primary endpoint
EASL LiverTree™, Maren Harms, 177565
Functional role of extracellular signal-regulated kinase 5 (ERK5) in cholangiocarcinoma (CCA) cells.
EASL LiverTree™, Alessandra Gentilini, 177566
Common variant p.D19H of the hepatobiliary sterol transporter ABCG8 is associated with increased gallstone risk and distorted sterol homeostasis in children
EASL LiverTree™, Marcin Krawczyk, 177567
Repopulating the biliary tree from the peribiliary glands
EASL LiverTree™, Robert Porte, 183727
Development of the biliary tree
EASL LiverTree™, Frederic Lemaigre, 183725
3D Anatomy of the biliary tree: Intravital two-photon based functional imaging of bile salt transport in cholestasis - pathophysiology of bile infarct formation
EASL LiverTree™, Jan Hengstler, 183724
State-of-the-Art lecture: Cholangiocyte pathobiology: Past, present and future
EASL LiverTree™, Nicholas LaRusso, 183721
Welcome and introductory remarks
EASL LiverTree™, Jesus M. Banales, 183718
Welcome and introductory remarks
EASL LiverTree™, Marco Marzioni, 183720
Best of Autoimmune and Cholestatic Liver Disease from ILC2017
EASL LiverTree™, Prof. Michael Manns and Dr. Gideon Hirschfield, 182281